The Effect of Eight Weeks of Concurrent Training on Serum Levels of Paraxonase-1, Irisin, Lipid Profile, and Insulin Resistance in Men With Metabolic Syndrome

Background: Irisin is a myokine suggested to exert anti-obesity benefits. On the other hand, paraxonase-1 (PON 1) one of most important free radical scavenging enzymes and among main protectors lipoproteins against oxidizing compounds. This study aimed evaluate effect 8 weeks concurrent training on serum levels irisin, PON 1, lipid profile, insulin resistance in men with metabolic syndrome. Methods: In this quasi-experimental study, 30 syndrome (aged 25-35 years body mass>25 kg.m-2) were purposefully selected randomly divided into two groups (n=15) control (n=15). Three sessions program held per week over an 8-week interval. Concurrent included warm-up, (20 minutes training), endurance (25 activity stationary bike intensity 50%-80% maximum heart rate). Blood samples collected before 24 hours after exercise measure variables. Data analyzed using independent dependent t-tests. Results: At baseline, high-density lipoprotein (HDL) higher group. The results also indicated that significantly reduced resistance, triglycerides (TG), cholesterol, low-density (LDL), systolic, diastolic blood pressure Conclusion: Eight improves profile